Basic Information
VIS ID
TVIS44005210
Fusion event
HTLV-1-CEP162 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
84922960/84213242 (Hg38)
End
84922960/84213242 (Hg38)
Orient
-
Location type
Intronic
Target gene
CEP162
miRNAs that regulate target gene
hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-513a-5p ; hsa-mir-4320 ; hsa-mir-3134 ; hsa-mir-383-5p ; hsa-mir-1245b-3p ; hsa-mir-1246 ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-6504-3p ; hsa-mir-6856-3p ; hsa-mir-3941 ; hsa-mir-3065-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485
Nearest miRNA
hsa-mir-10398/Upstream/5673933; hsa-mir-1202/Downstream/6099500;
Nearest TSS
ENST00000381078/Upstream/18212; ENST00000591225/Downstream/14354;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/179013, chr6-CpG: 42/Downstream/14156
Upstream sequence
TTGTTCTATCAAAAGCTAAAAATTTGGGAACTTTAAGGAAAACGTTTTGAAAATAAAGCATCTTCGAAGCATTTGATTAATTGCAGTTTAAAAGTAATAC
Downstream sequence
AAAGGAAAAAGATGCCCTATTTCTTAAATATACACAATTTTATTACTATGTGCATTTACATGTACAAATATTATCTTACAACCCTAGATATCCCTTCTAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate