VISDB - VIS Detail

Basic Information

VIS ID

TVIS44005212

Fusion event

HTLV-1-chr7 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr7

Cytoband

q11.21

Reference genome

GRCh37/hg19

Start

64313093/64852715 (Hg38)

End

64313093/64852715 (Hg38)

Orient

Location type

Intronic

Fragile sites / regions

FRA7J

Target gene

SEPHS1P1 ; ZNF138

miRNAs that regulate target gene

hsa-mir-183-3p ; hsa-mir-4709-3p ; hsa-mir-143-5p ; hsa-mir-3944-5p ; hsa-mir-298 ; hsa-mir-5681a ; hsa-mir-6845-3p ; hsa-mir-455-5p ; hsa-mir-656-3p ; hsa-mir-296-3p ; hsa-mir-8087 ; hsa-mir-135b-3p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-6754-3p ; hsa-mir-412-3p ; hsa-mir-3674 ; hsa-mir-629-3p ; hsa-mir-3925-3p ; hsa-mir-766-3p ; hsa-mir-770-5p ; hsa-mir-4712-5p ; hsa-mir-1-5p ; hsa-mir-4715-3p ; hsa-mir-3064-3p ; hsa-mir-23c ; hsa-mir-23b-3p ; hsa-mir-23a-3p ; hsa-mir-130a-5p ; hsa-mir-4732-5p ; hsa-mir-6832-5p ; hsa-mir-6837-3p ; hsa-mir-6509-3p ; hsa-mir-1257 ; hsa-mir-1273g-3p ; hsa-mir-181a-2-3p ; hsa-mir-200b-5p ; hsa-mir-200a-5p ; hsa-mir-4776-3p ; hsa-mir-7152-5p ; hsa-mir-3074-5p ; hsa-mir-4659b-5p ; hsa-mir-4659a-5p ; hsa-mir-5590-5p ; hsa-mir-19b-2-5p ; hsa-mir-19b-1-5p ; hsa-mir-19a-5p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-3124-3p ; hsa-mir-1914-5p ; hsa-mir-570-5p ; hsa-mir-548ba ; hsa-mir-548ai ; hsa-mir-548ag ; hsa-mir-561-3p ; hsa-mir-548at-5p ; hsa-mir-3692-3p ; hsa-mir-2054 ; hsa-mir-511-3p ; hsa-mir-6867-3p ; hsa-mir-4713-5p ; hsa-mir-2355-5p ; hsa-mir-491-5p ; hsa-mir-193b-5p ; hsa-mir-5589-3p ; hsa-mir-4729 ; hsa-mir-135a-3p ; hsa-mir-648 ; hsa-mir-670-3p

Nearest miRNA

hsa-mir-1183/Upstream/173539; hsa-mir-10399/Downstream/2261607;

Nearest TSS

ENST00000635602/Upstream/58225; ENST00000465954/Downstream/17457;

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/58026, chr7-CpG: 35/Downstream/29563

Upstream sequence

GTTGAGCCTCGCCATGTTCATCATCACCTCCTCGTAGGCCAGCTCTACATCTTCTTGGGTGACCACTAGTTTAATATTATTCCATTTCTTAGGAATATCC

Downstream sequence

AGCCACTGATGCACAGCCACTGCCCCCTGTGTCCCCAGGGGTTTTGTCAACACCAGCACATCCCCTGGTACTGCATTGTCTGGCATGATAAATTCACTGG

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.