Basic Information
VIS ID
TVIS44005224
Fusion event
HTLV-1-TMEM230 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
5089152/5108506 (Hg38)
End
5089152/5108506 (Hg38)
Orient
-
Location type
Intronic
Target gene
TMEM230
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/1190935; hsa-mir-1-1/Downstream/2263102;
Nearest TSS
ENST00000382410/Upstream/40352; ENST00000486875/Downstream/4247;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/106762, chr20-CpG: 73/Downstream/4208
Upstream sequence
aaaactccgtctccaaaaaaaaaaaaaaaaaaggaaaagaaGGCAATTTCAGCTTATTCCAAATGATTAGTTGTTTGTTCCACATAGCAAGTAAACCTGC
Downstream sequence
CTTATGAACAAATTCAATTCAAGGTTAAGATTCAGAGACAAATTTTCCAAGGTTTGGCTCATCGTTGTATCTGACCTAAGTGGCTGGAAGCTTCCCAGAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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