Basic Information
VIS ID
TVIS44005243
Fusion event
HTLV-1-ABCC12 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
48140098/48106187 (Hg38)
End
48140098/48106187 (Hg38)
Orient
-
Location type
Intronic
Target gene
ABCC12
miRNAs that regulate target gene
hsa-mir-6873-3p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-4291 ; hsa-mir-6817-3p ; hsa-mir-6787-3p ; hsa-mir-761 ; hsa-mir-3619-5p ; hsa-mir-214-3p ; hsa-mir-922 ; hsa-mir-141-5p ; hsa-mir-7110-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-6510-5p ; hsa-mir-505-5p ; hsa-mir-4254 ; hsa-mir-3690 ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-448 ; hsa-mir-19b-2-5p ; hsa-mir-19b-1-5p ; hsa-mir-19a-5p ; hsa-mir-1257 ; hsa-mir-15b-3p ; hsa-mir-6892-3p ; hsa-mir-4328 ; hsa-mir-153-3p ; hsa-mir-587 ; hsa-mir-6734-3p ; hsa-mir-1250-3p ; hsa-mir-4705 ; hsa-mir-6864-5p ; hsa-mir-6126 ; hsa-mir-6836-5p ; hsa-mir-6132 ; hsa-mir-4635 ; hsa-mir-5088-5p ; hsa-mir-5096 ; hsa-mir-576-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-513b-5p ; hsa-mir-642b-5p ; hsa-mir-6832-3p ; hsa-mir-4719 ; hsa-mir-4762-5p ; hsa-mir-3163 ; hsa-mir-216b-5p
Nearest miRNA
hsa-mir-1225/Upstream/13942514; hsa-mir-11401/Downstream/2186429;
Nearest TSS
ENST00000527434/Upstream/14949; ENST00000570174/Downstream/9246;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/644891, chr16-CpG: 31/Downstream/138234
Upstream sequence
ACTGCCCTTGGGGAGCAAACAAGCATCTTTCTTCTAAATGCCATTTTGCTGATTACAGTCATAGCGGAAATGTAAATCAGAGGTGGCTGATGGATGAACA
Downstream sequence
TCGTTAAAAGCAAAAGTATCTCTGGGGAGTTGAGGGATAGAAGGCCCAGCCTGAAGAGGAGACACTCCTGTGCCTTTGATTGTGCTGGGGCACCAGGGCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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