Basic Information
VIS ID
TVIS44005244
Fusion event
HTLV-1-KSR1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
25916750/27589724 (Hg38)
End
25916750/27589724 (Hg38)
Orient
+
Location type
Intronic
Target gene
KSR1
miRNAs that regulate target gene
hsa-mir-378a-3p ; hsa-mir-218-5p ; hsa-mir-4286 ; hsa-mir-140-3p ; hsa-mir-548e-5p
Nearest miRNA
hsa-mir-1180/Upstream/295728; hsa-mir-10226/Downstream/770930;
Nearest TSS
ENST00000595228/Upstream/2612; ENST00000579961/Downstream/2834;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/132392, chr17-CpG: 20/Downstream/15747
Upstream sequence
GATATACGTTAAAAAAAATCTGTGTTTCCAAAAATATGAGTTATTTCTGCTCTTAGGCCTCCCCACCCTGTGGACCAGCCTTGCACTTTTTTTCTGGAGG
Downstream sequence
ACACCACCCACTCAGCCCCCATCCTTCCTTCAAATCTATCTTTCGTGTTTTCTTTAATGTTCTACATTTTGGATTGAAAATACACTGATACGTTGAAACG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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