Basic Information
VIS ID
TVIS44005248
Fusion event
HTLV-1-LRPPRC integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p21
Reference genome
GRCh37/hg19
Start
44216044/43988905 (Hg38)
End
44216044/43988905 (Hg38)
Orient
-
Location type
Intronic
Target gene
LRPPRC
miRNAs that regulate target gene
hsa-mir-340-5p ; hsa-mir-16-5p ; hsa-mir-877-3p ; hsa-mir-576-5p ; hsa-mir-620 ; hsa-mir-4531 ; hsa-mir-1270 ; hsa-mir-4633-5p ; hsa-mir-139-3p ; hsa-mir-769-5p ; hsa-mir-432-5p ; hsa-mir-26a-2-3p ; hsa-mir-26a-1-3p ; hsa-mir-532-5p ; hsa-mir-6813-3p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p
Nearest miRNA
hsa-mir-1301/Upstream/8517419; hsa-mir-10b/Downstream/3388770;
Nearest TSS
ENST00000437798/Upstream/25101; ENST00000409486/Downstream/7071;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/156812, chr2-CpG: 80/Downstream/6697
Upstream sequence
gtgttgggattacaggcatgagccaccacgcctgaccAAATGCCTCTGAGTTTTTACAATATCtttcctttatcttttttttgagacagggtctcattct
Downstream sequence
gttgtccaggctggagtgcagtggtgcaattatggctcactgcagctttgaactcctggcctcaagcaatcctcccacctcagcctcagctcccaagtag
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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