Basic Information
VIS ID
TVIS44005254
Fusion event
HTLV-1-DSCAM integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
41714287/40342360 (Hg38)
End
41714287/40342360 (Hg38)
Orient
+
Location type
Intronic
Target gene
DSCAM
Nearest miRNA
hsa-let-7c/Upstream/129929; hsa-mir-3197/Downstream/825197;
Nearest TSS
ENST00000624081/Upstream/443884; ENST00000427451/Downstream/11294;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/159328, chr21-CpG: 34/Downstream/499224
Upstream sequence
ATATATAATATCTGTCAACATATATATGACACATATATTTGTGTGTGTATAaaatattttatcccagtctgtggttgcctttttcttttcttaataatgt
Downstream sequence
atttGTGTTGACATttaatgctttctgtgtcctaagaaatcgtcacctattcgcaaatcatgaagaattattctgttttcttttggagactgtgttgctt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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