Basic Information
VIS ID
TVIS44005255
Fusion event
HTLV-1-PRDM15 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
43271066/41850957 (Hg38)
End
43271066/41850957 (Hg38)
Orient
-
Location type
Intronic
Target gene
PRDM15
miRNAs that regulate target gene
hsa-mir-587 ; hsa-mir-583 ; hsa-mir-1276 ; hsa-mir-4311 ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-4529-5p ; hsa-mir-4635 ; hsa-mir-212-3p ; hsa-mir-132-3p
Nearest miRNA
hsa-let-7c/Upstream/104116; hsa-mir-5692b/Downstream/1099971;
Nearest TSS
ENST00000624081/Upstream/14025; ENST00000458654/Downstream/9421;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/15344, chr21-CpG: 25/Downstream/3559
Nearest cancer related gene
PRDM15(OG, No orient, 0)
Upstream sequence
ATTTAGAAGACGGCGCCACTGATCTGCAAAACTGACTGATTTCTACACGAAGATGCATGTTTGGAGCAAATCAAAGAGACAGAATTAAGTCACTGAGTCT
Downstream sequence
TAGGATCTCTCACGCTCACCAGGAAAGACTCGGCCACCACAATAAGTAATTTACAGGAAGACGGTTCCTGGGTTCGTCGGCTGCCAATACGGTTCTAGGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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