Basic Information
VIS ID
TVIS44005256
Fusion event
HTLV-1-KIAA1671 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
25470924/25074957 (Hg38)
End
25470924/25074957 (Hg38)
Orient
+
Location type
Intronic
Target gene
KIAA1671
miRNAs that regulate target gene
hsa-mir-1254 ; hsa-mir-1226-3p ; hsa-mir-940 ; hsa-mir-92b-5p ; hsa-mir-93-3p ; hsa-mir-590-5p ; hsa-mir-551b-3p ; hsa-mir-503-5p ; hsa-mir-423-3p ; hsa-mir-326 ; hsa-mir-192-5p ; hsa-mir-29b-3p ; hsa-mir-92a-3p ; hsa-mir-30a-3p ; hsa-mir-4252 ; hsa-mir-766-3p ; hsa-mir-4267 ; hsa-mir-6777-3p ; hsa-mir-508-5p ; hsa-mir-574-5p ; hsa-mir-1277-5p ; hsa-mir-6818-3p ; hsa-mir-190a-3p ; hsa-mir-6867-5p ; hsa-mir-4711-3p ; hsa-mir-223-5p ; hsa-mir-6895-3p ; hsa-mir-593-3p ; hsa-mir-5011-5p ; hsa-mir-335-3p ; hsa-mir-376a-3p ; hsa-mir-376b-3p ; hsa-mir-500a-3p ; hsa-mir-767-5p
Nearest miRNA
hsa-mir-1286/Upstream/2188578; hsa-let-7a-3/Downstream/380689;
Nearest TSS
ENST00000624155/Upstream/4988; ENST00000637069/Downstream/36885;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/46694, chr22-CpG: 62/Downstream/103952
Upstream sequence
tatgggatactggtttcatttcctttgggtatatgcccagaagagggattggtggatctattctcagttttttgaggaactatcatactattttacgtaa
Downstream sequence
caactTattttagaatacttgagaaaagttacaaagatagtagcgggagttcctgtatacccttcgcccggttcccctaatgttagcatgttactataac
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate