Basic Information
VIS ID
TVIS44005259
Fusion event
HTLV-1-ANK2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q25
Reference genome
GRCh37/hg19
Start
113782380/112861224 (Hg38)
End
113782380/112861224 (Hg38)
Orient
-
Location type
Intronic
Target gene
ANK2
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-335-5p ; hsa-mir-877-3p ; hsa-mir-647
Nearest miRNA
hsa-mir-12113/Upstream/212667; hsa-mir-1243/Downstream/245639;
Nearest TSS
ENST00000502981/Upstream/43115; ENST00000514246/Downstream/21106;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/154873, chr4-CpG: 86/Downstream/899689
Upstream sequence
AAACCAATTAAGTAAGTCTTGAACCGAAATTGCTTTTTATCATCTGGGTGAGAAGCCACAGATTTAAAGAAAAGGGCTATTGTTTTACAAAGACCTAATT
Downstream sequence
AGCTGGGCTACACTCAAGCTCTTGGGTTTTTATCTTATTAGAGAAAGGAAAGGTTGAAATTGCTTATGGGCTACTTCCTGGGTTGGAATTCCTAGGAATT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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