Basic Information
VIS ID
TVIS44005263
Fusion event
HTLV-1-COMMD10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
115528403/116192706 (Hg38)
End
115528403/116192706 (Hg38)
Orient
-
Location type
Intronic
Target gene
COMMD10
miRNAs that regulate target gene
hsa-mir-16-5p
Nearest miRNA
hsa-mir-10397/Upstream/5678791; hsa-mir-103a-1/Downstream/63037;
Nearest TSS
ENST00000502646/Upstream/101627; ENST00000508250/Downstream/98833;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/107238, chr5-CpG: 45/Downstream/168731
Upstream sequence
tccaacaaagacaaaaaagaataagaaaatatgaacaaagtttccaagaagtctgggattatgttaaacaacaaacctaagaataatcagtattactgag
Downstream sequence
gaagaagagatttctacaagcttggaaaacatatttgatggaatcatccaggaaaacttcgccagccttgctaggaacctagacatccaaatacaagaag
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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