Basic Information
VIS ID
TVIS44005270
Fusion event
HTLV-1-ORC5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
103788835/104148387 (Hg38)
End
103788835/104148387 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
ORC5
miRNAs that regulate target gene
hsa-mir-186-5p ; hsa-mir-100-5p ; hsa-mir-99a-5p ; hsa-mir-92a-3p ; hsa-mir-6829-5p ; hsa-mir-6762-3p ; hsa-mir-564 ; hsa-mir-5580-5p ; hsa-mir-3692-5p ; hsa-mir-330-3p ; hsa-mir-4446-3p
Nearest miRNA
hsa-mir-10525/Upstream/1676856; hsa-mir-10399/Downstream/10504958;
Nearest TSS
ENST00000635602/Upstream/158871; ENST00000401970/Downstream/17347;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/158120, chr7-CpG: 88/Downstream/180043
Upstream sequence
tccttatactaccccaAACAAGGAGCTATAGAATACAAAGAGATAATTTTGTTGGGCGAGATTAGGAAAGCTTTATGGAAGAAGGAAATGACTACTCCAC
Downstream sequence
CTTGCATTCTACAGTGAAGGCAATAACTATTAGTATGCTGGAAAAGTAAGAAACCCAGGAGAGCAGGCAATGCAAGTAAAACAGAGAAAAAGCCTTAAAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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