Basic Information
VIS ID
TVIS44005281
Fusion event
HTLV-1-TP53BP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q15.3
Reference genome
GRCh37/hg19
Start
43767699/43475501 (Hg38)
End
43767699/43475501 (Hg38)
Orient
-
Location type
Intronic
Target gene
TP53BP1
miRNAs that regulate target gene
hsa-mir-505-3p ; hsa-mir-361-5p ; hsa-mir-182-5p
Nearest miRNA
hsa-mir-1233-1/Upstream/1275835; hsa-mir-10393/Downstream/318158;
Nearest TSS
ENST00000557528/Upstream/19170; ENST00000382031/Downstream/17585;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/104033, chr15-CpG: 22/Downstream/17544
Nearest cancer related gene
TP53BP1(TSG, No orient, 0)
Upstream sequence
CTGCcttcaacagttcttcatccccaaagctctaatgcataggttctaccatttggtttcaAAAAGAATTCTAGACTAGCAGATAAGTTTAGCCTCTTTC
Downstream sequence
AGCCTTAGCCTAAGACTCTCAGGCACATACTGCCTTGGCATAAGCTATTTTAGGCTTACTTACGTGGAAAGACTGTCCTGAACAAGGGACCTCTGACCAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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