Basic Information
VIS ID
TVIS44005303
Fusion event
HTLV-1-chr11 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p14.2
Reference genome
GRCh37/hg19
Start
27043388/27021841 (Hg38)
End
27043388/27021841 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA11D
Nearest miRNA
hsa-mir-210/Upstream/3602651; hsa-let-7a-2/Downstream/493129;
Nearest TSS
ENST00000527297/Upstream/27657; ENST00000531832/Downstream/18884;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/689576, chr11-CpG: 29/Downstream/341231
Nearby gene
BBOX1(+19121) ;
Upstream sequence
TCAAGTTTTTTTAACTCATAGAGTGCTGTAATAAACATCATTTTGCATACACGATTATGCATATAAAAAATTATTTCTATAAACCAGAAAACTAGAAAAG
Downstream sequence
CAACTTCTGGGCCAAAATTTtatgtatctgtataccttattggctctgtttctttgaagaatactgactaataAACTGTCTAAATTCCTTGGAAAAAATA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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