Basic Information
VIS ID
TVIS44005311
Fusion event
HTLV-1-PCCA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
100819842/100167588 (Hg38)
End
100819842/100167588 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA13D
Target gene
PCCA
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-455-5p ; hsa-mir-7152-5p ; hsa-mir-568 ; hsa-mir-1273e ; hsa-mir-155-5p ; hsa-mir-4326 ; hsa-mir-15b-3p ; hsa-mir-486-5p
Nearest miRNA
hsa-mir-1297/Upstream/524439; hsa-mir-1267/Downstream/1800054;
Nearest TSS
ENST00000623511/Upstream/18387; ENST00000443601/Downstream/125636;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/78037, chr13-CpG: 51/Downstream/364554
Upstream sequence
gcagtgagctgtggagtgttactgcagtccagcctgggtgacaaaagaagaatgtgtctcaaaataatgaattatttaaaaaaatagatatatgtaattt
Downstream sequence
cttgccaaactcaaggtcactgagactttcttgttttttgttttgtatttttaatgttttatagttttagatctctgatcaattttgagttaatttttat
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate