Basic Information
VIS ID
TVIS44005314
Fusion event
HTLV-1-ARHGAP5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q12
Reference genome
GRCh37/hg19
Start
32588617/32119411 (Hg38)
End
32588617/32119411 (Hg38)
Orient
+
Location type
Intronic
Target gene
ARHGAP5
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-128-3p ; hsa-mir-106a-5p ; hsa-mir-17-5p ; hsa-mir-486-5p ; hsa-mir-494-3p ; hsa-mir-770-5p ; hsa-mir-493-5p ; hsa-mir-493-3p ; hsa-mir-744-5p
Nearest miRNA
hsa-mir-208a/Upstream/1104669; hsa-mir-1185-1/Downstream/4832898;
Nearest TSS
ENST00000550708/Upstream/25373; ENST00000216743/Downstream/34599;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/41476, chr14-CpG: 53/Downstream/81800
Upstream sequence
ACTTAAAGATTGTGATATTTTGCTGTTTATAGATCCTTAGATGTAGTGATATAAATGATCAGTAATTGTGTTGTTATAATCAGTCCTCTTATTTAAAAGA
Downstream sequence
CTAACCTTTCTTGAACAACCATGAAGAAAATATTGACAGttttaagaatcagctttattgatgtaatttacatacaataaaatttgctagtttgaatcgt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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