Basic Information
VIS ID
TVIS44005322
Fusion event
HTLV-1-RPAIN integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
5332695/5429375 (Hg38)
End
5332695/5429375 (Hg38)
Orient
-
Location type
UTR3
Target gene
RPAIN
miRNAs that regulate target gene
hsa-mir-940 ; hsa-mir-149-5p ; hsa-mir-107 ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-1253/Upstream/459225; hsa-mir-10226/Downstream/1226065;
Nearest TSS
ENST00000595228/Upstream/9173; ENST00000571506/Downstream/3501;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/8979, chr17-CpG: 56/Downstream/9530
Upstream sequence
cagacatggagatCTGGTGAGTTGTGGGGGTAGAGCTTAAGTGGAAGATCCCCACATAGAAGAACAAGGCAGAGAAGCAGGAAACTGGAGTATATACAAA
Downstream sequence
GAGCATCTTGTTCTACTTAGCTGGAGCATTAGGTTCATGAGGGAGAGGATAGTTCCTGTTAGGAATaggaaacagattcagagaagtgatgtaatctggc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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