Basic Information
VIS ID
TVIS44005323
Fusion event
HTLV-1-KRT17P3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
28896122/30569104 (Hg38)
End
28896122/30569104 (Hg38)
Orient
-
Location type
Intronic
Target gene
KRT17P3
Nearest miRNA
hsa-mir-1180/Upstream/451932; hsa-mir-10226/Downstream/525246;
Nearest TSS
ENST00000595228/Upstream/3528; ENST00000581019/Downstream/158460;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/91429, chr17-CpG: 113/Downstream/30970
Nearby gene
TBC1D29P(+5613) ;
Upstream sequence
CATCTGGACCCATCCTGACCTCTCACTCCCAAGCCTTCCCCTACGAGGGGACCCCACTCCCCACAAGGACCCCTCCTTTGTTCTCCCTCTGCTCTGTCTG
Downstream sequence
ACCCTCTAAATGATTTTTATTCATCTGCTCAGTATTGCCTCCACCATCAGACTCTATCTCCCCCATTAGACCAAGGGCTCTCCAAAATAAAATCTAATTA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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