Basic Information
VIS ID
TVIS44005326
Fusion event
HTLV-1-ACYP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p16.2
Reference genome
GRCh37/hg19
Start
54440582/54213445 (Hg38)
End
54440582/54213445 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2D ; FRA2H
Target gene
ACYP2
Nearest miRNA
hsa-mir-1301/Upstream/364240; hsa-mir-10b/Downstream/1769522;
Nearest TSS
ENST00000437798/Upstream/90266; ENST00000486488/Downstream/42827;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/97494, chr2-CpG: 36/Downstream/42342
Upstream sequence
ggcatctagatggattccatgtctttgctcttatgaatagtactgtgataaacatatacgtgcacgtgtctttatggtagaatgatttatattcctttgg
Downstream sequence
gtatagacccagtaatgagatttctgggtcaaatagcagttctgttttaagttctttgagaaatctccaaactgctttctaatttattcccaccagcagt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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