Basic Information
VIS ID
TVIS44005331
Fusion event
HTLV-1-PLCB1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
8851315/8870668 (Hg38)
End
8851315/8870668 (Hg38)
Orient
+
Location type
Intronic
Target gene
PLCB1
miRNAs that regulate target gene
hsa-mir-423-5p ; hsa-mir-30c-5p ; hsa-mir-297 ; hsa-mir-4325 ; hsa-mir-6867-5p ; hsa-mir-567 ; hsa-mir-223-5p ; hsa-mir-3607-5p ; hsa-mir-511-3p ; hsa-mir-502-3p ; hsa-mir-501-3p
Nearest miRNA
hsa-mir-103a-2/Upstream/1498976; hsa-mir-1-1/Downstream/1778968;
Nearest TSS
ENST00000382410/Upstream/80446; ENST00000637254/Downstream/10232;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/737723, chr20-CpG: 107/Downstream/197643
Upstream sequence
AAAGTTTAAAAAGGAAATGCATGTTAGGAACTGTGCTTGGTAAATCACATGGTCTCTAGTTTCTGTCTTTCCTCTTTTATTGATTCAGTATTTGGATCTA
Downstream sequence
CTTAGTATTTTGCCTACCTCGTCCTTGACTCCTCCAACCTTCCTTTCTGGCAACTTAGCAACCCTCATTCTGCCCTTCACCCAACAGCCTTATCAACACT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate