Basic Information
VIS ID
TVIS44005335
Fusion event
HTLV-1-chr22 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.32
Reference genome
GRCh37/hg19
Start
48882407/48486595 (Hg38)
End
48882407/48486595 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA22A
Nearest miRNA
hsa-let-7a-3/Upstream/212180; hsa-mir-12114/Downstream/293700;
Nearest TSS
ENST00000624155/Upstream/37705; ENST00000406880/Downstream/2865;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/152015, chr22-CpG: 203/Downstream/2477
Nearby gene
TAFA5(+2865) ;
Upstream sequence
CCCCACTCCTCAGGTCCGTCTACTTGTAACCTGGGGTGGAGAATTCACCTTTTCTAGCGTCACCATTTTCAGACTCTCCACCATTCTAGACTCCAAGTCA
Downstream sequence
TAAGCACCAAGGGCTCCCCTTCCATTCCCTTTTTCTGGAAATATTCAGCATGTAATGAACCAGGCACTGCTCTCCCATAGCCCAAGGTTCCCCGCCATAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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