Basic Information
VIS ID
TVIS44005359
Fusion event
HTLV-1-EXD3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q34.3
Reference genome
GRCh37/hg19
Start
140282517/137388065 (Hg38)
End
140282517/137388065 (Hg38)
Orient
-
Location type
Intronic
Target gene
EXD3
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-let-7a-1/Upstream/218795; hsa-mir-602/Downstream/61961;
Nearest TSS
ENST00000422679/Upstream/21433; ENST00000392815/Downstream/7343;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/5875, chr9-CpG: 27/Downstream/6136
Upstream sequence
GATGGCCCTGGCCAGGAGGCTGGGCCCTGACCCTGGACCCTGCCCCTTGGAACCATGTGGGTGGGGGCAGAGCGGGGCAGCTGTGTATTAGGAGGACACC
Downstream sequence
TAGAAAAAACTCAAGCTCAAGAATAAAAGTCCCACAGTCCCCCGAATGTGGATTCACATCCAAGAGCTGGGCTGCTTCTCTCTGGGGGGCTGAATCATGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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