Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene171259487171812254173041559172143822172144270172143650172143799172150523
Basic Information
VIS ID
TVIS44005385
Fusion event
HTLV-1-GALNTL6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q34.1
Reference genome
GRCh37/hg19
Start
173071674/172150523 (Hg38)
End
173071674/172150523 (Hg38)
Orient
-
Location type
Intronic
Target gene
GALNTL6
miRNAs that regulate target gene
hsa-mir-4309 ; hsa-mir-3198 ; hsa-mir-6844 ; hsa-mir-9-5p
Nearest miRNA
hsa-mir-12113/Upstream/964231; hsa-mir-1305/Downstream/1117637;
Nearest TSS
ENST00000502981/Upstream/98078; ENST00000457021/Downstream/115631;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/336556, chr4-CpG: 154/Downstream/1018269
Upstream sequence
GCTAAGAGAGAAGAGAAATGAGTTACATGAGTAGAATGGTAGTGAAGGGGCTACTTTAGATTTGGGGCAGGGACAGAAAAATCTTTTTGAGAAAGTGTTC
Downstream sequence
TTTTAGCCAAGTCCCCTTTAGTCAGTAAAGAGTGCAGCAATGATGTTGCATAGAAAGGAAATAGTATGTGAATATTTGTGGATGTAAAACAACCCTTGGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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