Basic Information
VIS ID
TVIS44005394
Fusion event
HTLV-1-ZMYND11 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p15.3
Reference genome
GRCh37/hg19
Start
281714/235774 (Hg38)
End
281714/235774 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZMYND11
miRNAs that regulate target gene
hsa-mir-361-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-324-5p ; hsa-mir-125b-5p ; hsa-mir-27b-3p ; hsa-mir-222-3p ; hsa-mir-10b-5p ; hsa-mir-548q ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-4747-5p ; hsa-mir-5196-5p ; hsa-mir-6828-5p ; hsa-mir-138-5p ; hsa-mir-1468-3p ; hsa-mir-548f-5p ; hsa-mir-548g-5p ; hsa-mir-548x-5p ; hsa-mir-548aj-5p ; hsa-mir-4484 ; hsa-mir-548an ; hsa-mir-4698 ; hsa-mir-548aw ; hsa-mir-6768-3p
Nearest miRNA
hsa-mir-107/Downstream/405915;
Nearest TSS
ENST00000439456/Upstream/37833; ENST00000488275/Downstream/4188;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/99262, chr10-CpG: 32/Downstream/64790
Nearest cancer related gene
ZMYND11(TSG, No orient, 0)
Upstream sequence
ATTGGCGTAAACGGAGCAGCTGTGGGCACAGGCCACAAAGCGGCATAAGGAGAGGGCACTGACTGCGTTGCCAGAGAACCTAGGTGAGAAGTGGGGTCAG
Downstream sequence
GAAGGTGCAGTGCAGACATGAGGTAAATGAAATTCAGTTTAGTTTCTCACTAATAAAATGTGTTTCCACTTGTTATTTAGATATTTTATGTGTTTATAAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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