Basic Information
VIS ID
TVIS44005397
Fusion event
HTLV-1-MLX integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
40719741/42567723 (Hg38)
End
40719741/42567723 (Hg38)
Orient
+
Location type
Intronic
Target gene
MLX
miRNAs that regulate target gene
hsa-mir-33a-5p ; hsa-mir-320b ; hsa-mir-484 ; hsa-mir-378a-3p ; hsa-mir-320a ; hsa-mir-149-5p ; hsa-mir-218-5p ; hsa-mir-92a-3p ; hsa-mir-1229-5p ; hsa-mir-16-2-3p ; hsa-mir-195-3p ; hsa-mir-197-5p ; hsa-mir-198 ; hsa-mir-2115-3p ; hsa-mir-2278 ; hsa-mir-3132 ; hsa-mir-3170 ; hsa-mir-329-5p ; hsa-mir-342-5p ; hsa-mir-34a-3p ; hsa-mir-369-3p ; hsa-mir-374a-5p ; hsa-mir-374b-5p ; hsa-mir-4260 ; hsa-mir-4464 ; hsa-mir-4468 ; hsa-mir-4505 ; hsa-mir-450a-2-3p ; hsa-mir-4651 ; hsa-mir-4664-5p ; hsa-mir-4748 ; hsa-mir-520a-5p ; hsa-mir-525-5p ; hsa-mir-5572 ; hsa-mir-5589-5p ; hsa-mir-5692b ; hsa-mir-5692c ; hsa-mir-5787 ; hsa-mir-608 ; hsa-mir-6501-3p ; hsa-mir-6737-5p ; hsa-mir-6747-5p ; hsa-mir-6786-3p ; hsa-mir-6812-5p ; hsa-mir-6819-5p ; hsa-mir-6855-5p ; hsa-mir-6861-5p ; hsa-mir-8081
Nearest miRNA
hsa-mir-1180/Upstream/53416; hsa-mir-10226/Downstream/140361;
Nearest TSS
ENST00000595228/Upstream/442; ENST00000588320/Downstream/354;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/108, chr17-CpG: 48/Downstream/9703
Upstream sequence
GTATGCCTACAGCGACAACAGCCTGGACCCCGGTGAGTAGCTGCCCCATCTTAAGCTCTAGAGGGACACTCCCGCCCAGGCTCTCTAGATTCTTGTGGCG
Downstream sequence
TTGCCAACCACGCCTGAGCACAGTCCACTCTCCCTGAGCAGAGTTCCTGGCTTGAGACAGCAGGAGCTGAAGGACAAGGGCAGAAAACAACTGAGGGTGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate