Basic Information
VIS ID
TVIS44005400
Fusion event
HTLV-1-ZNF362 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p35.1
Reference genome
GRCh37/hg19
Start
33740408/33274807 (Hg38)
End
33740408/33274807 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZNF362
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-6772-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-7106-3p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-6832-3p ; hsa-mir-4286 ; hsa-mir-3121-3p ; hsa-mir-335-3p ; hsa-mir-5696
Nearest miRNA
hsa-mir-12136/Upstream/1187800; hsa-mir-101-1/Downstream/57586;
Nearest TSS
ENST00000473358/Upstream/4232; ENST00000477934/Downstream/5543;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/17743, chr1-CpG: 54/Downstream/1366
Upstream sequence
AAGACTAGGGTTTGCAAAGCAAATTCCCCAGAGGAACCAGCTTGAGCaaatctgatttctagttttgactgtggcaccttcgctttgtggccttggacag
Downstream sequence
gtctcctccttcccctctctctgagcctcagtttcttcactgataaaatggtataataatacctcttgtgcctactttcaagtaaagatcacaagagata
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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