Basic Information
VIS ID
TVIS44005406
Fusion event
HTLV-1-FAM216A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.11
Reference genome
GRCh37/hg19
Start
110914371/110476566 (Hg38)
End
110914371/110476566 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
FAM216A
miRNAs that regulate target gene
hsa-mir-877-3p ; hsa-mir-149-5p ; hsa-mir-576-5p ; hsa-mir-498 ; hsa-mir-4279 ; hsa-mir-6778-3p ; hsa-mir-4735-5p ; hsa-mir-1281 ; hsa-mir-4485-5p ; hsa-mir-4726-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6840-3p ; hsa-mir-5571-5p
Nearest miRNA
hsa-let-7i/Upstream/643130; hsa-mir-1178/Downstream/827576;
Nearest TSS
ENST00000382841/Upstream/7298; ENST00000547539/Downstream/9735;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/7188, chr12-CpG: 54/Downstream/25085
Upstream sequence
caaagcgctgggattacaggtgtgagccaccgcgcctggccTAATGTTTTTATGTTTCTTAGCttttttcttttttttgagacgaagtctcactctgtcg
Downstream sequence
cccaggctggagtgttgttgcacaatcttggctcaccgcaacctctgccccaccaggttcaagcagttcttgtgtctcagcctctcgagtagctgggatt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate