Basic Information
VIS ID
TVIS44005409
Fusion event
HTLV-1-TADA2A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q12
Reference genome
GRCh37/hg19
Start
35812064/37451962 (Hg38)
End
35812064/37451962 (Hg38)
Orient
-
Location type
Intronic
Target gene
TADA2A
miRNAs that regulate target gene
hsa-mir-5096 ; hsa-mir-197-3p ; hsa-mir-6832-5p ; hsa-mir-411-5p ; hsa-mir-873-3p ; hsa-mir-4716-5p ; hsa-mir-4676-3p ; hsa-mir-892c-3p ; hsa-mir-452-5p ; hsa-mir-4727-5p ; hsa-mir-6873-3p ; hsa-mir-4684-5p ; hsa-mir-942-5p ; hsa-mir-6817-5p ; hsa-mir-4769-3p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-153-5p ; hsa-mir-487a-3p ; hsa-mir-154-3p ; hsa-mir-302f ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-3145-3p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-541-5p ; hsa-mir-335-3p ; hsa-mir-511-5p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5696 ; hsa-mir-4711-3p ; hsa-mir-6830-3p ; hsa-mir-6866-3p ; hsa-mir-188-5p
Nearest miRNA
hsa-mir-1180/Upstream/418149; hsa-mir-10226/Downstream/162969;
Nearest TSS
ENST00000595228/Upstream/1397; ENST00000616284/Downstream/9858;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/44995, chr17-CpG: 148/Downstream/37222
Upstream sequence
aatcccagctacttgggaggcaggggcaggagaattgcttgagcctgggagacagaggttgcagtgagccaagactgcgctgttgcactccagcctgggc
Downstream sequence
gacaagagcaaaactgtctcaaaaataaaaaataaaTCACAAAAATGTTTTGTTAAAATTAGCAGTAATTTTACTGGCTCTTCAAGACATTTTCTTTCCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate