Basic Information
VIS ID
TVIS44005411
Fusion event
HTLV-1-PIK3R2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.11
Reference genome
GRCh37/hg19
Start
18276320/18165510 (Hg38)
End
18276320/18165510 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
PIK3R2
miRNAs that regulate target gene
hsa-mir-126-3p ; hsa-mir-30c-5p ; hsa-mir-133a-3p ; hsa-mir-296-3p ; hsa-mir-93-5p ; hsa-mir-30d-5p ; hsa-mir-552-3p ; hsa-mir-30a-5p ; hsa-mir-122-5p ; hsa-mir-1295b-5p ; hsa-mir-143-5p ; hsa-mir-1912 ; hsa-mir-3130-5p ; hsa-mir-3135b ; hsa-mir-3652 ; hsa-mir-4430 ; hsa-mir-4482-5p ; hsa-mir-504-3p ; hsa-mir-5591-3p ; hsa-mir-564 ; hsa-mir-5693 ; hsa-mir-5698 ; hsa-mir-6499-3p ; hsa-mir-6728-3p ; hsa-mir-891a-3p
Nearest miRNA
hsa-mir-10395/Upstream/2715902; hsa-let-7e/Downstream/116567;
Nearest TSS
ENST00000633603/Upstream/3464; ENST00000459743/Downstream/766;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/4088, chr19-CpG: 18/Downstream/1634
Upstream sequence
gtaataccagctacttggaaggctgaggcaggagaatcacttgaacccaagaggcagaggttgcagtgagccaagatcacgccactgctccagcctgggc
Downstream sequence
gacaagagcaagactccatctcaaacaaaaaaaattttgaggtgctgtctcaccatgttgcccaggctggcctcagactcctcagggttcaagagatcct
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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