Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene181946609181891833181930738181889761181901497181887851181891663181875726181877774181857161181858213181850801181851695181861256181861767181858434181858843181874233181874631181862954181863103181898705
Basic Information
VIS ID
TVIS44005413
Fusion event
HTLV-1-ITPRID2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
182763432/181898705 (Hg38)
End
182763432/181898705 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2G
Target gene
ITPRID2
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-128-3p ; hsa-mir-101-3p ; hsa-mir-32-5p ; hsa-mir-21-5p ; hsa-mir-25-3p ; hsa-mir-92a-3p ; hsa-mir-146a-3p ; hsa-mir-363-3p ; hsa-mir-367-3p ; hsa-mir-92b-3p ; hsa-mir-935 ; hsa-mir-3646 ; hsa-mir-3662 ; hsa-mir-6796-3p ; hsa-mir-545-5p ; hsa-mir-875-5p ; hsa-mir-4777-3p ; hsa-mir-15b-3p ; hsa-mir-137 ; hsa-mir-4766-5p ; hsa-mir-136-5p ; hsa-mir-3185 ; hsa-mir-3658 ; hsa-mir-4302 ; hsa-mir-4426 ; hsa-mir-4474-5p ; hsa-mir-4647 ; hsa-mir-4662b ; hsa-mir-4697-3p ; hsa-mir-494-3p ; hsa-mir-6733-3p ; hsa-mir-7856-5p
Nearest miRNA
hsa-mir-10b/Upstream/593053; hsa-mir-1244-1/Downstream/2480270;
Nearest TSS
ENST00000437798/Upstream/5312; ENST00000470654/Downstream/154;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/5913, chr2-CpG: 53/Downstream/817261
Upstream sequence
GTTCCCTATACGTTTTTTTATTTTAAGCACTCAAGTGAGAGTAGTTAGTTTCATGTTGCCACAACACAAAAACACCCTTCAAAAGCTCCTGGCCCTGTTC
Downstream sequence
TTATCTATCTGTATATCACTTTTAATAATGCAGATTTAATGGACCAAGATAAGTGTTTAATATATTTGGCATTTAATTCTAATATTGTAGGTAATTAGAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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