Basic Information
VIS ID
TVIS44005417
Fusion event
HTLV-1-ARHGEF26 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
153965722/154247933 (Hg38)
End
153965722/154247933 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA3D
Target gene
ARHGEF26
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-130a-3p ; hsa-mir-188-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-1260a ; hsa-mir-3121-3p ; hsa-mir-3156-3p ; hsa-mir-1260b ; hsa-mir-4295 ; hsa-mir-4301 ; hsa-mir-3666 ; hsa-mir-4452 ; hsa-mir-3974 ; hsa-mir-4671-3p ; hsa-mir-3591-5p ; hsa-mir-4473 ; hsa-mir-506-3p ; hsa-mir-124-3p ; hsa-mir-3119 ; hsa-mir-216a-5p ; hsa-mir-216b-5p ; hsa-mir-22-3p ; hsa-mir-3679-3p ; hsa-mir-545-5p ; hsa-mir-548c-3p ; hsa-mir-6758-5p ; hsa-mir-6856-5p ; hsa-mir-6873-5p ; hsa-mir-7705 ; hsa-mir-329-5p
Nearest miRNA
hsa-let-7g/Upstream/2681938; hsa-mir-1224/Downstream/5034713;
Nearest TSS
ENST00000440867/Upstream/22148; ENST00000497890/Downstream/29902;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/125342, chr3-CpG: 49/Downstream/180625
Upstream sequence
CCTAAGTCATGGTATCGTCAATGAGACAATACTCTGTGAAAAATACAGAAGTCTACCCTTTATAAAAGGACAAAGGAAGAATGTTTTACCACTGTCATTC
Downstream sequence
TTTTTTCCCTCTGGGCCTTTCAAGAGGAATGTGGGAGCCAGAGAGCCCCCTTTGTCTGCCTTCATTAAAATGAAGCACAGACAGCTGCAGCTGGCACACA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate