Basic Information
VIS ID
TVIS44005431
Fusion event
HTLV-1-NUDT13 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
74883108/73123350 (Hg38)
End
74883108/73123350 (Hg38)
Orient
-
Location type
Intronic
Target gene
NUDT13
miRNAs that regulate target gene
hsa-mir-186-5p
Nearest miRNA
hsa-mir-1265/Upstream/402250; hsa-mir-107/Downstream/2429108;
Nearest TSS
ENST00000439456/Upstream/12820; ENST00000607940/Downstream/2055;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/26123, chr10-CpG: 25/Downstream/44534
Upstream sequence
TCATTCTAATTTCTTTTTTGAATACAGGTGAATAAAAATGTTTCCATATAGCTCTGGGTCCACAGACCTGCCATTGGGAACCACTTTGCTATTGGCTCAT
Downstream sequence
GGCTCCTGTCAGGCTTTCCTTCTGTCTTTAATGGTCTAGGTGTAAATGTAGTGATGCTGGGATGAGGTTCACATAGGAGCCATGAGGTCCCACTTCATCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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