Basic Information
VIS ID
TVIS44005447
Fusion event
HTLV-1-SLC8A2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.32
Reference genome
GRCh37/hg19
Start
47950646/47447389 (Hg38)
End
47950646/47447389 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
SLC8A2
Nearest miRNA
hsa-mir-10395/Upstream/220368; hsa-let-7e/Downstream/1562517;
Nearest TSS
ENST00000633603/Upstream/14821; ENST00000593284/Downstream/233;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/16819, chr19-CpG: 89/Downstream/223
Upstream sequence
CACAAGCCTCTCCCCACATCTCCCTGGGTACTCTTCAGCACACACTCCACGAGCTACCAATTAAGGCCCCACACCGCTCTCCCCAGGCCCCGTCCCATCT
Downstream sequence
CTCCTCACCTCGTCCCCCCTTCCTCCTTGGGGCCCTCTTCTCACCTGTCCGGCCACCCTTCTAGGCCTCGCCTCTTCATTTCACAGTCACAACCCCACCA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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