Basic Information
VIS ID
TVIS44005448
Fusion event
HTLV-1-chr2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p21
Reference genome
GRCh37/hg19
Start
46455432/46228293 (Hg38)
End
46455432/46228293 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA2S
Nearest miRNA
hsa-mir-1301/Upstream/10756807; hsa-mir-10b/Downstream/1149382;
Nearest TSS
ENST00000437798/Upstream/60315; ENST00000460015/Downstream/65374;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/575747, chr2-CpG: 289/Downstream/68357
Nearby gene
PRKCE(+40303) ;
Nearest cancer related gene
PRKCE(TSG, +40303) ;
Upstream sequence
agtttgataggagaggcaattacagtaaaacgtgagaaatacaatataatggttatagacaaagactggtgggactcacaggagtcaaaatgtctgacta
Downstream sequence
gagaaggcatcactgacaagtgacacctggatcgagtcttcaagaacatgtgagaatttaccaggcagaGAATTGATTGATTGCTGGGTGGAACCCAGGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate