Basic Information
VIS ID
TVIS44005465
Fusion event
HTLV-1-TNS3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
47371747/47332149 (Hg38)
End
47371747/47332149 (Hg38)
Orient
-
Location type
Intronic
Target gene
TNS3
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-21-5p ; hsa-mir-342-3p ; hsa-let-7i-5p ; hsa-mir-8070 ; hsa-mir-5003-5p ; hsa-mir-8485 ; hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-1178-3p ; hsa-mir-6071 ; hsa-mir-6749-3p ; hsa-mir-377-3p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-5088-3p
Nearest miRNA
hsa-mir-1183/Upstream/2450349; hsa-mir-10399/Downstream/9623636;
Nearest TSS
ENST00000635602/Upstream/51831; ENST00000429010/Downstream/68289;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/77461, chr7-CpG: 95/Downstream/204562
Upstream sequence
ACCCTTCTGCAAGTCTCACAATCCCAGACCCTCCCAAGTGTGTCAAAAAGAATGGGTGCATTTTGGCCAGGAATCACAGCCTGAAGGGACAGTGGTAACA
Downstream sequence
GGTGCTTCAGAGAAAATGCCCAGGCATTTTACCTCTTGACGCCCAGTGCTCTTGGGACACCACTGTGAGGCAGGCTGCTGTCTAGAGGGGATGGAACTGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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