Basic Information
VIS ID
TVIS44005466
Fusion event
HTLV-1-VGF integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
100812757/101169476 (Hg38)
End
100812757/101169476 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
VGF
miRNAs that regulate target gene
hsa-mir-6885-5p ; hsa-mir-328-5p ; hsa-mir-4697-5p ; hsa-mir-4488 ; hsa-mir-1237-5p ; hsa-mir-6787-5p ; hsa-mir-663a ; hsa-mir-1908-5p ; hsa-mir-8072 ; hsa-mir-3960 ; hsa-mir-4479 ; hsa-mir-3195
Nearest miRNA
hsa-mir-10525/Upstream/9921; hsa-mir-10399/Downstream/1123627;
Nearest TSS
ENST00000635602/Upstream/3883; ENST00000461205/Downstream/9760;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/3693, chr7-CpG: 117/Downstream/2727
Nearby gene
NAT16(No orient, 1017)
Upstream sequence
AAACCACTTCTGTCATCCTGAACCAGCCTCCTTCAACTTCCACCTGTCACACACATAACACACTGTCCTACAGAATCACACTGAGATTCGGAGACACACC
Downstream sequence
CACTTACACAAACACAATGTCACACCTAGCCTAGCAGTTACCCAGACCTAGGCTGGAGATGTGTGCAGGGCAATGGAGGTGTGCTCTAAGTGTTCTCACT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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