Basic Information
VIS ID
TVIS44005489
Fusion event
HTLV-1-RABIF integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
202853168/202884040 (Hg38)
End
202853168/202884040 (Hg38)
Orient
+
Location type
Intronic
Target gene
RABIF
miRNAs that regulate target gene
hsa-mir-488-3p ; hsa-mir-5579-3p ; hsa-mir-4538 ; hsa-mir-4453 ; hsa-mir-561-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-629-3p ; hsa-mir-6867-3p ; hsa-mir-4713-5p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-2116-3p ; hsa-mir-150-5p ; hsa-mir-1224-3p ; hsa-mir-5571-5p
Nearest miRNA
hsa-mir-101-1/Upstream/880804; hsa-mir-1182/Downstream/2564262;
Nearest TSS
ENST00000473358/Upstream/73078; ENST00000463015/Downstream/5095;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/22245, chr1-CpG: 83/Downstream/4515
Upstream sequence
AAGGACCATTGCTAGGGCCAGGAGATTAGCTACAACATCCGGAATGTAATGAGGCTTTCTGGATAGACTACTGGGGATGGCAACAAAAAAATTAGTATGT
Downstream sequence
AATTTGAGGCAAACTCAACTTGGTGCGAAGTTGCCAGTGAGATCTCTGACCAGATGGGTTGGTTACCTTTGTTCTGTCAGGACCCCAGCGAATCCTGGAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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