Basic Information
VIS ID
TVIS44005494
Fusion event
HTLV-1-PKD2L1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q24.31
Reference genome
GRCh37/hg19
Start
102080515/100320758 (Hg38)
End
102080515/100320758 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
PKD2L1
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-107/Upstream/1396190; hsa-mir-1307/Downstream/654227;
Nearest TSS
ENST00000439456/Upstream/34046; ENST00000370355/Downstream/9182;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/33883, chr10-CpG: 133/Downstream/25667
Upstream sequence
tgagaaaagtgtccaacctcattggtaataaaaggcaagtaaattaatgtgagttgtaccatcttatacctatttaataataaaaattatgaatgagaac
Downstream sequence
atccaattttgatgaggttgtgacaaaattgatgtgatcttatagcactagtggcataataagtttgtataatcccttacagaggcaaaatgacaacaca
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate