Basic Information
VIS ID
TVIS44005519
Fusion event
HTLV-1-TPP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
103299317/102646967 (Hg38)
End
103299317/102646967 (Hg38)
Orient
+
Location type
Intronic
Target gene
TPP2
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-1297/Upstream/600963; hsa-mir-1267/Downstream/4884204;
Nearest TSS
ENST00000623511/Upstream/19821; ENST00000490420/Downstream/2088;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/49325, chr13-CpG: 154/Downstream/125981
Upstream sequence
TGAAACACACATCAGTTTGGTTATAATGTTAGGGAAATGGATTGGTTTCAGTGAATTTTCACATTTCAGTTTTATAAAGTAATTAGAGGTCCTGAAGTAT
Downstream sequence
GTATATGTTGCTTTATTAATGAATACACATAGCCAGGTGTGTATTTTTAAAAGTTTGTAAGAGAGCAGTGACTTTTATAAGTGCTAAAATACTGTGTGTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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