Basic Information
VIS ID
TVIS44005530
Fusion event
HTLV-1-chr16 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
52298829/52264917 (Hg38)
End
52298829/52264917 (Hg38)
Orient
-
Location type
Intronic
Target gene
CASC22 ; LOC105371261
Nearest miRNA
hsa-mir-1225/Upstream/1522540; hsa-mir-11401/Downstream/3980603;
Nearest TSS
ENST00000527434/Upstream/6353; ENST00000628396/Downstream/6655;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/1108568, chr16-CpG: 125/Downstream/280807
Upstream sequence
CTTTAAAAAAGAAATCGGAGGCTGGTGGTTAATAATGTGCCTGCCTTAAAGCTTAACAAAATAACTTCCCATCGAGTATCTGTAAATTAATGACTAATCC
Downstream sequence
AACTTTTAACACAAGTTCACTAGAAACAAATGTTTTACATATACATGGCAATCAATAAAGAAGACAAAAATATACGGATGTGTTTAATCATTTATTTCTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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