Basic Information
VIS ID
TVIS44005541
Fusion event
HTLV-1-POLI integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
51809234/54282864 (Hg38)
End
51809234/54282864 (Hg38)
Orient
+
Location type
Exonic
Fragile sites / regions
FRA18B
Target gene
POLI
miRNAs that regulate target gene
hsa-mir-92a-3p ; hsa-mir-27b-5p ; hsa-mir-4255 ; hsa-mir-3591-5p ; hsa-mir-5197-3p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-4760-5p ; hsa-mir-548aw ; hsa-mir-8061 ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-340-5p ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-4786-5p ; hsa-mir-769-5p ; hsa-mir-889-3p ; hsa-mir-1277-5p ; hsa-mir-142-3p ; hsa-mir-376a-5p ; hsa-mir-455-5p ; hsa-mir-203a-3p ; hsa-mir-3190-5p ; hsa-mir-3926 ; hsa-mir-513b-3p ; hsa-mir-548s ; hsa-mir-5583-3p ; hsa-mir-6849-3p
Nearest miRNA
hsa-mir-1-2/Upstream/1045674; hsa-mir-122/Downstream/1196357;
Nearest TSS
ENST00000575820/Upstream/4; ENST00000583576/Downstream/42;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/12902, chr18-CpG: 82/Downstream/74713
Upstream sequence
tataatattttaattaGCTTTGTTTTAAGGAGAAAAGCTATTTTAACATTGTATGCATTTCTTTTTATTTAGGTATTGGCTATAAAACTGCCAAATGTCT
Downstream sequence
TGAAGCACTGGGTATCAATAGTGTGCGTGATCTCCAAACCTTTTCACCCAAAATTTTAGAAAAAGAATTAGGAATTTCAGTTGCTCAGCGTATCCAAAAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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