Basic Information
VIS ID
TVIS44005548
Fusion event
HTLV-1-MBOAT2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
9042384/8902254 (Hg38)
End
9042384/8902254 (Hg38)
Orient
-
Location type
Intronic
Target gene
MBOAT2
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-7977 ; hsa-mir-513b-5p ; hsa-mir-7974 ; hsa-mir-4719 ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-4282 ; hsa-mir-6885-3p ; hsa-mir-887-5p ; hsa-mir-6779-5p ; hsa-mir-6780a-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-1273h-5p ; hsa-mir-30b-3p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-3977 ; hsa-mir-4291 ; hsa-mir-920 ; hsa-mir-6726-5p ; hsa-mir-5591-5p ; hsa-mir-4300 ; hsa-mir-6090 ; hsa-mir-6827-5p ; hsa-mir-7157-5p ; hsa-mir-4310 ; hsa-mir-4762-5p ; hsa-mir-8485 ; hsa-mir-3149 ; hsa-mir-4477a ; hsa-mir-496 ; hsa-mir-548as-3p ; hsa-mir-3613-3p ; hsa-mir-3074-5p ; hsa-mir-6868-3p ; hsa-mir-5581-5p ; hsa-mir-4297 ; hsa-mir-3667-3p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-1306-5p ; hsa-mir-6800-3p
Nearest miRNA
hsa-mir-7158/Upstream/2251815; hsa-mir-10b/Downstream/1290360;
Nearest TSS
ENST00000437798/Upstream/25120; ENST00000565044/Downstream/56336;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/64595, chr2-CpG: 135/Downstream/100744
Upstream sequence
agagcccttttccagaaagcctgacacccgtgtccgtagtccagcggccgtgctagtcgcttttaactggccaacaggtgcccagtatttagcccccaaa
Downstream sequence
ttctaaggaaaaataggacaaaatagcaaatgaaaggggtccgatggtactcaccacttggcgatAATCAGTGGTCCCTTTGTGGTCACCAAAAtgtgtc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate