Basic Information
VIS ID
TVIS44005576
Fusion event
HTLV-1-chr4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q23
Reference genome
GRCh37/hg19
Start
99388582/98467431 (Hg38)
End
99388582/98467431 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA4E
Nearest miRNA
hsa-mir-12113/Upstream/11166848; hsa-mir-1243/Downstream/529956;
Nearest TSS
ENST00000502981/Upstream/88272; ENST00000505408/Downstream/18101;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/205383, chr4-CpG: 97/Downstream/190560
Nearby gene
TSPAN5(-2936) ;
Upstream sequence
GAGGACACCTTTAGGACAGTGCCTCTGCCTGGAAGATGAGCAGCTTTAGGCAGTCACCATCGTCGTCTAGAAACCACATTTGAAAACTGGTGGGAGGACA
Downstream sequence
AGGCCCAGCTCCATCCTGCCGCGATAAACTCCCAGCAGCAAGATCCCAAGCAGGATAGATGGTGATGGGAGCAAAACGTCCTGTTCTCTCATCTTTCCAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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