Basic Information
VIS ID
TVIS44005582
Fusion event
HTLV-1-DSP integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
7563147/7562914 (Hg38)
End
7563147/7562914 (Hg38)
Orient
+
Location type
Intronic
Target gene
DSP
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-9-5p ; hsa-mir-34a-5p ; hsa-mir-16-5p ; hsa-mir-186-5p ; hsa-let-7e-5p ; hsa-mir-544a
Nearest miRNA
hsa-mir-3691/Upstream/1393479; hsa-mir-10398/Downstream/2876803;
Nearest TSS
ENST00000381078/Upstream/3628; ENST00000634363/Downstream/27285;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/19675, chr6-CpG: 55/Downstream/27252
Nearest cancer related gene
DSP(TSG, No orient, 0)
Upstream sequence
ATATCTACCGAAGGATCGTGTAATTACTCAATCCCAGGGAGTTTCTTCTGAAACATTGCTATTATTTCTTTCCCAGAAGACTGGAAATGTTTAGAAATCC
Downstream sequence
CACTTCTTAAATGGGGAAGTGGAATCAGTAGCCCTATTAGAGATTATGTTAACACTTGAAGAGGAGTTAAACCAGAGGCTGAGGTTGTGCAAACACTCAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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