Basic Information
VIS ID
TVIS44005589
Fusion event
HTLV-1-C1GALT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
7278822/7239191 (Hg38)
End
7278822/7239191 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7B
Target gene
C1GALT1
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-375 ; hsa-mir-98-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-4753-3p ; hsa-mir-196a-3p ; hsa-mir-627-3p ; hsa-mir-130b-5p ; hsa-mir-4742-5p ; hsa-mir-8063 ; hsa-mir-3065-5p ; hsa-mir-216b-5p ; hsa-mir-548s ; hsa-mir-4684-5p ; hsa-mir-3926 ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-339-5p ; hsa-mir-548al ; hsa-mir-4445-3p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-6732-3p ; hsa-mir-548as-3p
Nearest miRNA
hsa-mir-339/Upstream/172146; hsa-mir-10399/Downstream/10888029;
Nearest TSS
ENST00000635602/Upstream/4871; ENST00000433056/Downstream/121268;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/55848, chr7-CpG: 85/Downstream/327550
Upstream sequence
AATCAGCAGTAGtcacttagcaaatagctattgatgctgttatatgccaggcactgagaatgtagaagtaaatcacagccaatttccagttctcgtgaac
Downstream sequence
cttacattctggatgaggagatatacagtaaacaggcagacttgtaaatataaaataggattttagtagtaagtgccctgaagaaaaataagccaagtaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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