Basic Information
VIS ID
TVIS44005613
Fusion event
HTLV-1-MIPOL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
37758323/37289118 (Hg38)
End
37758323/37289118 (Hg38)
Orient
+
Location type
Intronic
Target gene
MIPOL1
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-let-7a-3p ; hsa-mir-1277-5p ; hsa-mir-4666b ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-6867-5p ; hsa-mir-3650 ; hsa-mir-380-3p ; hsa-mir-411-3p ; hsa-mir-379-3p ; hsa-mir-4495 ; hsa-mir-4517 ; hsa-mir-5001-3p ; hsa-mir-4279 ; hsa-mir-4497 ; hsa-mir-5581-5p ; hsa-mir-4297 ; hsa-mir-6778-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-150-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-6814-5p ; hsa-mir-122-3p ; hsa-mir-96-5p ; hsa-mir-1271-5p ; hsa-mir-183-5p ; hsa-mir-593-5p ; hsa-mir-5571-5p
Nearest miRNA
hsa-mir-208a/Upstream/336727; hsa-mir-1185-1/Downstream/10471877;
Nearest TSS
ENST00000550708/Upstream/3745; ENST00000556940/Downstream/19340;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/90830, chr14-CpG: 123/Downstream/294322
Upstream sequence
ATAGCCACGTTAGTTTTTATAGCCAAAGTGTGCCCTGTTGTTTAATCTTAACTTTAAAAGGATTGAATAATCATTGCTGGAAGTTTTATCATAGATGGCA
Downstream sequence
TTTTTATCCCTGAATTTTTTATTGTGAGGAATCCCTGGGTGTGTCAGTGGAAACAGAAACACAAACTCAGTGCACttcttttctcttattcaacacaaca
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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