Basic Information
VIS ID
TVIS44005617
Fusion event
HTLV-1-ATP2C1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
130607187/130888343 (Hg38)
End
130607187/130888343 (Hg38)
Orient
+
Location type
Intronic
Target gene
ATP2C1
miRNAs that regulate target gene
hsa-mir-18a-3p
Nearest miRNA
hsa-let-7g/Upstream/1616100; hsa-mir-1224/Downstream/1097512;
Nearest TSS
ENST00000440867/Upstream/37560; ENST00000508297/Downstream/5625;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/141487, chr3-CpG: 97/Downstream/5098
Upstream sequence
gaggagtcacttttgttgcttcaagctgtgctgcctggggttgggggaaggatggcacaagcactcccttagattccctggctagtgtctccccaggtca
Downstream sequence
tgtaccaccctagtccagtggctctaagcccatcccagcccagcactagaagttgcctaagaactgcaatccctgtgtcctagacagactttcaagttta
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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