Basic Information
VIS ID
TVIS44005634
Fusion event
HTLV-1-CISD1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
60030126/58270366 (Hg38)
End
60030126/58270366 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10C
Target gene
CISD1
miRNAs that regulate target gene
hsa-mir-92b-3p ; hsa-mir-128-3p ; hsa-mir-92a-3p ; hsa-mir-4662a-5p ; hsa-mir-379-5p ; hsa-mir-3529-5p ; hsa-mir-3651 ; hsa-mir-6831-5p ; hsa-mir-3927-3p ; hsa-mir-3156-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-188-3p ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-4668-5p ; hsa-mir-3148 ; hsa-mir-662 ; hsa-mir-141-5p ; hsa-mir-129-5p
Nearest miRNA
hsa-mir-1265/Upstream/965807; hsa-mir-107/Downstream/5102591;
Nearest TSS
ENST00000439456/Upstream/1188; ENST00000489785/Downstream/3020;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/885, chr10-CpG: 65/Downstream/64605
Upstream sequence
TCCACTTCTGTTGACAAAATTTACCTGGCTAAGGGTGATATTCCATGACATTTCGAAGTTACTAATGATATAGAGATTATTATTTGCAAAAATTATATTA
Downstream sequence
AAGGATACTCATCTTGAGACTTTTTTTAATAGAGGCAGCTTGGTGCATTTAAAATAGGGTGTGATTTTTGTTTTTGTTTTTTAAAAAACTATATTCTCTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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