Basic Information
VIS ID
TVIS44005642
Fusion event
HTLV-1-MYH3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
10563531/10660214 (Hg38)
End
10563531/10660214 (Hg38)
Orient
+
Location type
Intronic
Target gene
MYH3
Nearest miRNA
hsa-mir-1253/Upstream/2473210; hsa-mir-10226/Downstream/1421685;
Nearest TSS
ENST00000595228/Upstream/1132; ENST00000584139/Downstream/20520;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/21737, chr17-CpG: 78/Downstream/36894
Nearby gene
MYH3(-2905) ;
Upstream sequence
ccttcgtcttctcctctgtaaaacgggggtgacatacctgcctcccagactagttatgtgcattcagcgggataTCCCAACATCGCACACACCATGCCTC
Downstream sequence
GTGCTGTGTTTGGTACATTGCAGGTGTTTGCCAGGTGTAAGTTTTCTTCTCTACCTGCAGATTATGGCACAGTGTGACTGGTTTTCTTAATGAGAACCCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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