Basic Information
VIS ID
TVIS44005652
Fusion event
HTLV-1-CDK7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
68559063/69263236 (Hg38)
End
68559063/69263236 (Hg38)
Orient
+
Location type
Intronic
Target gene
CDK7
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-423-3p ; hsa-mir-199a-3p
Nearest miRNA
hsa-mir-10397/Upstream/9559533; hsa-mir-103a-1/Downstream/2906231;
Nearest TSS
ENST00000502646/Upstream/28093; ENST00000511349/Downstream/57344;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/28062, chr5-CpG: 35/Downstream/69359
Upstream sequence
AGAGAGAAAGATGCTGACTTGGAAACTTCTCTTTAGCTATGAAGTTTAGATCTCCAGAAAGACTAGCCCTTACGAATGATGAAGGTAAAGGGATACAGGG
Downstream sequence
GAATCCTTCTGAAGCTAGTTTTTTTCTCTCCATATTCTGACCCCTGCTCTCCCTCTCCTTAAGCCATATGTATTTAAAGAAATTCAAACCAAGATTGAAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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